publications

For a full current list of publications check out Nate's google scholar page

  1. Brown, C. M.; Lundberg, D. J.; Lamb, J. R.; Kleinschmidt, D.; Yasmeen, S.; Ottaviani, M. F.; Oldenhuis, N.J.;* Johnson, J. A.* Plug-and-Play Heterogeneous Catalysis Enabled by Metal – Organic Cage-Crosslinked Polymers. Chemrxiv 2021, No. I, 1–13. https://doi.org/10.26434/CHEMRXIV-2021-W5KZ4.

  2. Nguyen, H. V. T.; Jiang, Y.; Mohapatra, S.; Wang, W.; Barnes, J. C.; Oldenhuis, N. J.; Chen, K. K.; Axelrod, S.; Huang, Z.; Chen, Q.; et al. Bottlebrush Polymers with Flexible Enantiomeric Side Chains Display Differential Biological Properties. Nat. Chem. 2022, 14 (1), 85–93. https://doi.org/10.1038/s41557-021-00826-8.

  3. Oldenhuis, N. J.; Whittaker, A. M.; Dong, V. M. Greener Methods for Amide Bond Synthesis. In Methods in Pharmacology and Toxicology; Humana, New York, NY, 2022; pp 35–96. https://doi.org/10.1007/978-1-0716-1579-9_2.

work prior to UNH

  1. Oldenhuis, N. J.; Qin, K. P.; Wang, S.; Ye, H.; Alt, E. A.; Willard, A. P.; Van Voorhis, T.; Craig, S. L.; Johnson, J. A. Photoswitchable Sol–Gel Transitions and Catalysis Mediated by Polymer Networks with Coumarin‐Decorated Cu 24 L 24 Metal–Organic Cages as Junctions. Angew. Chemie 2020, 132 (7), 2806–2814.  https://doi.org/10.1002/ange.201913297

  2. Manna, S.;+ Howitz, W. J.;+ Oldenhuis, N. J.; Eldredge, A. C.; Shen, J.; Nihesh, F. N.; Lodoen, M. B.; Guan, Z.; Esser-Kahn, A. P. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture. ACS Cent. Sci. 2018, 4 (8), 982–995. https://doi.org/10.1021/acscentsci.8b00218.

  3. Golder, M. R.; Nguyen, H. V. T.; Oldenhuis, N. J.; Grundler, J.; Park, E. J.; Johnson, J. A. Brush-First and ROMP-Out with Functional (Macro)Monomers: Method Development, Structural Investigations, and Applications of an Expanded Brush-Arm Star Polymer Platform. Macromolecules 2018, 51 (23), 9861–9870. https://doi.org/10.1021/acs.macromol.8b01966.

  4. Neal, J. A.;+ Oldenhuis, N. J.;+ Novitsky, A. L.; Samson, E. M.; Thrift, W. J.; Ragan, R.; Guan, Z. Large Continuous Mechanical Gradient Formation via Metal–Ligand Interactions. Angew. Chemie 2017, 129 (49), 15781–15785. https://doi.org/10.1002/ange.201707587.

  5. Mood, A. D.; Premachandra, I. D. U. A.; Hiew, S.; Wang, F.; Scott, K. A.; Oldenhuis, N. J.; Liu, H.; Van Vranken, D. L. Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against Candida Albicans. ACS Med. Chem. Lett. 2017, 8 (2), 168–173. https://doi.org/10.1021/acsmedchemlett.6b00355.

  6. Oldenhuis, N. J.; Eldredge, A. C.; Burts, A. O.; Ryu, K. A.; Chung, J.; Johnson, M. E.; Guan, Z. Biodegradable Dendronized Polymers for Efficient MRNA Delivery. ChemistrySelect 2016, 1 (15), 4413–4417. https://doi.org/10.1002/slct.201600939.

  7. Johnson, M. E.; Shon, J.; Guan, B. M.; Patterson, J. P.; Oldenhuis, N. J.; Eldredge, A. C.; Gianneschi, N. C.; Guan, Z. Fluorocarbon Modified Low-Molecular-Weight Polyethylenimine for SiRNA Delivery. Bioconjug. Chem. 2016, 27 (8), 1784–1788. https://doi.org/10.1021/acs.bioconjchem.6b00216.

  8. Eldredge, A. C.; Johnson, M. E.; Oldenhuis, N. J.; Guan, Z. Focused Library Approach to Discover Discrete Dipeptide Bolaamphiphiles for SiRNA Delivery. Biomacromolecules 2016, 17 (10), 3138–3144. https://doi.org/10.1021/acs.biomac.6b00635.

  9. Zeng, H.; Johnson, M. E.; Oldenhuis, N. J.; Tiambeng, T. N.; Guan, Z. Structure-Based Design of Dendritic Peptide Bolaamphiphiles for SiRNA Delivery. ACS Cent. Sci. 2015, 1 (6), 303–312. https://doi.org/10.1021/acscentsci.5b00233.

  10. Oldenhuis, N. J.; Dong, V. M.; Guan, Z. Catalytic Acceptorless Dehydrogenations: Ru-Macho Catalyzed Construction of Amides and Imines. Tetrahedron 2014, 70 (27–28), 4213–4218. https://doi.org/10.1016/j.tet.2014.03.085.

  11. Oldenhuis, N. J.; Dong, V. M.; Guan, Z. From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination. J. Am. Chem. Soc. 2014, 136 (36), 12548–12551. https://doi.org/10.1021/ja5058482.

  12. Yang, Y.; Oldenhuis, N. J.; Buchwald, S. L. Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts. Angew. Chemie Int. Ed. 2013, 52 (2), 615–619. https://doi.org/10.1002/anie.201207750.

  13. Breitler, S.; Oldenhuis, N. J.; Fors, B. P.; Buchwald, S. L. Synthesis of Unsymmetrical Diarylureas via Pd-Catalyzed C-N Cross-Coupling Reactions. Org. Lett. 2011, 13 (12), 3262–3265. https://doi.org/10.1021/ol201210t.