top of page


For a full current list of publications check out Nate's google scholar page


3.  Endohedrally Functionalized Metal–Organic Cage-Cross-Linked Polymer Gels as Modular Heterogeneous Catalysts
Christopher M. Brown, David J. Lundberg, Jessica R. Lamb, Ilia Kevlishvili, Denise Kleinschmidt, Yasmeen S. Alfaraj, Heather J. Kulik, Maria Francesca Ottaviani, Nathan J. Oldenhuis,* and Jeremiah A. Johnson*
Journal of the American Chemical Society 2022, 144, 13276-13284

2. Bottlebrush polymers with flexible enantiomeric side chains display differential biological properties

Hung V.-T. Nguyen, Yivan Jiang, Somesh Mohapatra, Wencong Wang, Jonathan C. Barnes, Nathan J. Oldenhuis, Kathleen K. Chen, Simon Axelrod, Zhihao Huang, Qixian Chen, Matthew R. Golder, Katherine Young, Dylan Suvlu, Yizhi Shen, Adam P. Willard, Michael J. A. Hore, Rafael Gómez-Bombarelli & Jeremiah A. Johnson 

Nature Chemistry 2022, 14, 85-93

1. Greener Methods for Amide Bond Synthesis

Nathan J. Oldenhuis, Aaron M. Whittaker & Vy M. Dong 

Richardson, P.F. (eds) Green Chemistry in Drug Discovery. Methods in Pharmacology and Toxicology. Humana, New York, NY.

work prior to UNH

​(1)        Oldenhuis, N. J.; Qin, K. P.; Wang, S.; Ye, H.; Alt, E. A.; Willard, A. P.; Van Voorhis, T.; Craig, S. L.; Johnson, J. A. Photoswitchable Sol–Gel Transitions and Catalysis Mediated by Polymer Networks with Coumarin‐Decorated Cu24L24 Metal–Organic Cages as Junctions. Angew. Chemie Int. Ed. 2020, 59 (7), 2784–2792.

(2)        Golder, M. R.; Nguyen, H. V. T.; Oldenhuis, N. J.; Grundler, J.; Park, E. J.; Johnson, J. A. Brush-First and ROMP-Out with Functional (Macro)Monomers: Method Development, Structural Investigations, and Applications of an Expanded Brush-Arm Star Polymer Platform. Macromolecules 2018, 51 (23), 9861–9870.

(3)        Manna, S.; Howitz, W. J.; Oldenhuis, N. J.; Eldredge, A. C.; Shen, J.; Nihesh, F. N.; Lodoen, M. B.; Guan, Z.; Esser-Kahn, A. P. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture. ACS Cent. Sci. 2018, 4 (8), 982–995.

(4)        Neal, J. A.; Oldenhuis, N. J.; Novitsky, A. L.; Samson, E. M.; Thrift, W. J.; Ragan, R.; Guan, Z. Large Continuous Mechanical Gradient Formation via Metal–Ligand Interactions. Angew. Chemie 2017, 129 (49), 15781–15785.

(5)        Mood, A. D.; Premachandra, I. D. U. A.; Hiew, S.; Wang, F.; Scott, K. A.; Oldenhuis, N. J.; Liu, H.; Van Vranken, D. L. Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against Candida Albicans. ACS Med. Chem. Lett. 2017, 8 (2), 168–173.

(6)        Eldredge, A. C.; Johnson, M. E.; Oldenhuis, N. J.; Guan, Z. Focused Library Approach to Discover Discrete Dipeptide Bolaamphiphiles for SiRNA Delivery. Biomacromolecules 2016, 17 (10), 3138–3144.

(7)        Oldenhuis, N. J.; Eldredge, A. C.; Burts, A. O.; Ryu, K. A.; Chung, J.; Johnson, M. E.; Guan, Z. Biodegradable Dendronized Polymers for Efficient MRNA Delivery. ChemistrySelect 2016, 1 (15), 4413–4417.

(8)        Johnson, M. E.; Shon, J.; Guan, B. M.; Patterson, J. P.; Oldenhuis, N. J.; Eldredge, A. C.; Gianneschi, N. C.; Guan, Z. Fluorocarbon Modified Low-Molecular-Weight Polyethylenimine for SiRNA Delivery. Bioconjug. Chem. 2016, 27 (8), 1784–1788.

(9)        Zeng, H.; Johnson, M. E.; Oldenhuis, N. J.; Tiambeng, T. N.; Guan, Z. Structure-Based Design of Dendritic Peptide Bolaamphiphiles for SiRNA Delivery. ACS Cent. Sci. 2015, 1 (6), 303–312.

(10)      Oldenhuis, N. J.; Dong, V. M.; Guan, Z. From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination. J. Am. Chem. Soc. 2014, 136 (36), 12548–12551.

(11)      Oldenhuis, N. J.; Dong, V. M.; Guan, Z. Catalytic Acceptorless Dehydrogenations: Ru-Macho Catalyzed Construction of Amides and Imines. Tetrahedron 2014, 70 (27–28), 4213–4218.

(12)      Yang, Y.; Oldenhuis, N. J.; Buchwald, S. L. Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts. Angew. Chemie Int. Ed. 2013, 52 (2), 615–619.

(13)      Breitler, S.; Oldenhuis, N. J.; Fors, B. P.; Buchwald, S. L. Synthesis of Unsymmetrical Diarylureas via Pd-Catalyzed C-N Cross-Coupling Reactions. Org. Lett. 2011, 13 (12), 3262–3265.

bottom of page